الفهرس 
Pro-Adreno medullin as a diagnostic and prognostic marker in children with Community acquired pneumonia
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Abstract
Background: Community acquired pneumonia is a major health problem and one of the most important causes of mortality in Egypt and all the developing countries, it consumes many efforts and costs to cover hospital admission and treatment so it should be well known how to assess the severity of the disease to take the right decision either to manage at home or to admit to general ward or ICU. Objectives: To measure the level of a new biomarker pro-adrenomedullin and compare it to other biomarkers like CRP , WBC or Neutrophil band percentage. Also to assess its relation with outcome and severity . Methods: 50 patients from Cairo University Hospitals aging from 1 month to 5 years presenting with Community acquired pneumonia in the form of dysnea , fever, respiratory distress , cough and chest x-ray with positive findings and 50 controls free of any chest disease, cardiac problem or endocrinal one. All of the children are subjected to full clinical evaluation and withdrawal of blood sample to measure pro- adrenomedullin using ELISA kits , full complete blood count, CRP ..Follow up of the outcome for 2 weeks. Results: Median level of pro-adrenomedullin was higher in cases than in control patients (12.2 and 5.7) ng/L respectively, P- value was not statistically significant between pro- adrenomedullin and CRP , WBC, NBP. Also P {u2013} value was not significant between pro-adrenomedullin and outcome, pediatric respiratory severity scoring or respiratory distress grading., pro-adrenomedullin was found to be 98% sensitive and 62% specific to community acquired pneumonia