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Abstract This study was done aiming at investigating the role of M. pneumoniae, C. pneumoniae and L. pneumophilia in (CAP) in children. This study included 200 Egyptian children aged from more than one month to 12 years presented to emergency department of Cairo university children’s hospital with CAP. Nasopharyngeal aspirate were examined for these three atypical pathogens using multiplex (PCR). The study showed that atypical pathogens represent 1% of CAP in children |