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العنوان
Synthesis of some novel bis (heterocycles) utilizing bis (difunctional) compounds as precursors /
الناشر
Soad Kamal Salama Arafat ,
المؤلف
Soad Kamal Salama Arafat
هيئة الاعداد
باحث / Soad Kamal Salama Arafat
مشرف / Ahmed Helmy Mahmoud Elwahy
مشرف / Ismail Abdelshafy Abdelhamid
مشرف / Ahmad Fathy Darweesh
تاريخ النشر
2016
عدد الصفحات
110 P. ;
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Organic Chemistry
تاريخ الإجازة
20/6/2017
مكان الإجازة
جامعة القاهرة - كلية العلوم - Organic Chemistry
الفهرس
Only 14 pages are availabe for public view

from 175

from 175

Abstract

A simple, efficient and ecofriendly procedure has been developed for the synthesis of bis(4H-chromene-3-carbonitrile) derivatives using chitosan as catalyst under microwave-assisted reaction conditions. For the sake of comparison, the reaction was also carried out under conventional heating in the presence of each of chitosan and piperidine as basic catalysts. An efficient and convenient route for the synthesis of novel bis(1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile) and bis(5,7-diamino-3-methyl- 1,4-dihydropyrazolo[4’,3’:5,6]pyrano[2,3-b]pyridine-6-carbonitrile) were reported. The synthetic pathway involves one pot multi-component reaction of bis-aldehydes, malononitrile or dimer malononitrile, and pyrazolone in the presence of Piperidine/EtOH.A stepwise approach for the synthesis of the target compounds was also investigated. The structures of all compounds are confirmed based on the different spectral tools