الفهرس 
Title : Estimation of salivary levels of interleukine-6 (IL-6) and interleukine-8 (IL-8) in the oral pre-malignant and malignant lesions
ContantsOnly 14 pages are availabe for public view
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Abstract
Oral cancer refers to all malignancies arising from the lips and the oral cavity. It affects more than 481,000 new patients worldwide. It is the sixth most common cancer in the USA. The 90% of oral cancers are oral squamous cell carcinoma. This cancer, when found early, has an 80 to 90% survival rate. Despite this fact and the great treatment advances, the World Health Organization has reported oral cancer as having one of the highest mortality ratios amongst other malignancies with a death rate at five years from diagnosis at 45 %. This high morbidity rate can definitely be attributed to the late diagnosis of the disease. It has been proven that NF-kappa B-dependent cytokines (interleukins (IL-1, -6, -8, and tumor necrosis factor (TNF)-Ü) are produced by OSCC cells .Furthermore, expression profiling of OSCC using microarray indicated that IL-6 and IL-8 are significantly over expressed by these tumors. A role of cytokines in angiogenesis and tumor progression has been suggested This study was carried out on 50 subjects where they were subdivided into 15 patients suffering from frank oral malignancy, 20 patients with oral premalignant lesions: among the 20 patients, biopsy results enabled us to further subdivide the group into patients with dysplastic lesions and others with no dysplastic changes; 10 patients into each group. And further comparing the two groups with 15 control subjects. The results showed that carcinoma showed the statistically significantly highest mean IL-8 level. OPL with dysplasia showed statistically significantly lower mean value followed by OPL without dysplasia. Control group showed the statistically significantly lowest mean IL-8 level. Also, Carcinoma showed the statistically significantly highest mean IL-6 level. OPL with dysplasia showed statistically significantly lower mean value followed by OPL without dysplasia