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Abstract This study was conducted to evaluate the effect of dietary supplementation of 4% mentha piperita powder and 4% ethanol extract of mentha piperita on the growth performance ,haematological ,biochemical ,immunological parameters and disease resistance against streptococcus species in oreochromis niloticuus and at the same time comparing between using of 4% mentha piperita powder and 4% ethanol extract of mentha piperita .the results revealed that there was significant increase in growth in groups fed enrich diet than control group ,But there was no significant difference beteween groups fed diet supplemented with 4% mentha piperita powder and groups fed diet supplemented with 4% ethanol extract of mentha piperita. there was no significant difference in Hb ,PCV,RBCs count , WBCs count, ALT ,AST ,uric acid, urea ,creatinine and albumin between different groups. there was significant increase in globulin and total protein in groups fed enriched diet when compared with control group, But there was no significant difference beteween groups fed diet supplemented with 4% mentha piperita powder and groups fed diet supplemented with 4% ethanol extract of mentha piperita. There was no significant difference in lysozyme activity and nitric oxide activity between different groups. There was reduction in mortality after bacterial challenge with streptococcus species in groups fed enriched diet when compared with control group |