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Abstract
Background and aim: non alcoholic fatty liver disease (NAFLD) is an increasing health problem which affects about 1/3 of the population worldwide, it is strongly associated with metabolic syndrome with oxidative stress and insulin resistance are the mechanisms mostly involved in its pathogenesis. Dipeptidyl peptidase -4 inhibitors are antidiabetic agents expected to have beneficial effects beyond their glycemic control. Accordingly the present work was designed to study the beneficial effects of sitagliptin (a DPP-4I) on a dietary model of NAFLD. Experimental approach: 120 male albino rats were allocated in 10 groups. Groups I,II represent the normal control, Groups III,IV represent the HFD induced NAFLD model, the effects of prophylactic use of sitagliptin, silymarin or their compination were assessed in groups V, VI, VII respectively and their potential therapeutic effects were assessed in groups VIII, IX,X. body weight and blood pressure were recorded and blood samples were tested for total cholesterol, triglycerides and liver transaminases, glucose and insulin levels . Livers were removed and weighed, parts were used for GSH, MDA,TGF-B and DPP-4 activity and other parts were kept for histopatholgical examination. Aortae were removed for in vitro vascular reactivity studies