الفهرس Only 14 pages are availabe for public view
 |  | from | 120 |  |  |
| | | from | 120 | | |
Abstract
Dihydrofolate reductase (DHFR) is an enzyme that catalyzes the reduction of folic acid or dihydrofolic acid into tetrahydrofolic acid which then converted into N5, N10-methylenetetrahydrofolate. This later compound functions as the source of the methyl group to convert dUMP into dTMP. So, Inhibition of DHFR has long been an attractive goal for the development of agents against bacterial and parasitic infections as well as cancer.Quinazoline derivatives constitute an important class of heterocyclic compounds; many of them possessed a wide range of biological activities as anti-inflammatory, analgesic, antifungal, antibacterial, anticancer and anticonvulsant activities. Accordingly, A new series of 2-mercapto-quinazolin-4-one analogues was designed, synthesized and evaluated for their in vitro DHFR inhibition, antimicrobial and antitumor activities