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Abstract
Despite recent progress in cancer therapy, there is still urgent need to search for newer and safer anticancer agents. Encouraged by the marked cytotoxic activity exhibited by some 2-substituted benzimidazole derivatives, adapting different mechanism of actions, it seemed of interest to design and synthesize novel VEGFR-2 and c-Met kinase dual inhibitors bearing 5-nitrobenzimidazole scaffold aiming to explore potential anticancer agents