الفهرس 
Synthesis and Studying the Anticipated Biological Activity of Novel Heterocycles
ABSTRACTOnly 14 pages are availabe for public view
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Abstract
Part 1: The cyclocondensation reaction of aldehydes with dimedone and bis(6-aminopyrimidin4-one) in acetic acid led to the formation of the corresponding bis(pyrimido[4,5-b]quinoline-4,6-
diones) which are known as bis(sulfanediyl)bis(tetrahydro-5-deazaflavin) analogs in a single
step. Also, bis(pyrimido[4,5-b]quinoline-4,6-diones) which are linked to naphthyl core via
phenoxymethyl linkage is prepared. The interactions of the synthesized compounds with DNA
and bovine serum albumin (BSA) were studied. Gel electrophoresis assay used to show the
capability of the compounds to photocleave the supercoiled plasmid DNA (pBR322 plasmid
DNA) in UV-A (365 nm). Besides, the most photocleavable compound, 14b, exhibits good
binding affinities toward DNA and BSA using UV-Vis spectral method. Molecular docking
methods were also used for modeling the binding of the 14b to DNA and BSA and good
agreements were found between the experimental and theoretical results.
Part 2: A simple, and efficient procedure has been developed for the synthesis of a new series
of 1,4-dihydropyridin-3,5-dicarbonitriles, hexahydroacridine-1,8-diones, 7,14-dihydro-6H,8Hdichromeno[4,3-b:3’,4’-e]pyridine-6,8-diones, and 1,4,7,8-tetrahydrodipyrazolo[3,4-b:4’,3’-
e]pyridines which are linked to phenoxy-N-arylacetamide utilizing 2-(4-formylphenoxy)-Narylacetamides as precursors.