الفهرس 
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Abstract
Diabetes mellitus and its complications are rapidly becoming the world’s most significant cause of morbidity and mortality (Jang et al, 2011).Diabetic retinopathy, the most common microvascular complication of DM, is predicted to be the principal reason of new blindness among working population (Aiello et al, 2003).Aim of our study is to verify the reliability of PTX3 as a marker of DR progression and prediction.Our study was carried in internal medicine department and outpatient clinic and ophthalmology clinic at Ahmed Maher Teaching Hospital.The study included 20 healthy individuals as a control group, 20 prediabetic patients and 60 diabetic patients aged from 40 to 75 years, the disease duration ranged from 5 -22 years and they were classified into 5 groups:group A: contains 20 normal persons as a control group.group B: contains 20 prediabetic patientsbased on fasting and post prandial blood glucose level.group C: contains 20 diabetic patients without diabetic changes of their retina.group D: contains 20 diabetic patients with non-proliferative diabetic retinopathy.group E: contains 20 diabetic patients with proliferative diabetic retinopathy.We have searched for diabetic retinopathy through fundus examination using direct and indirect ophthalmoscope in addition to fluorescein angiography.We have studied the relation between serum pentraxin 3 levels and diabetic retinopathy in a way to prove that elevated serum pentraxin 3 level is associated with development of diabetic retinopathy.Patients with history of cardiac disease, past history of stroke, Patients with any form of chronic infection, malignancies, Patients with current or history of receiving any form of immune-modulating drugs, end stage renal disease, Patients with severe eye disease or retinal detachment and intra-venous recreational drug users have been excluded.