الفهرس 
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Abstract
etic peripheral neuropathy can injure the hand median nerve and cause extensive nerve damage. We hypothesized a genetic association between the aldose reductase (ALR) polymorphisms (-106C→T and -12C→G) and elevated serum protein kinase C (PKC-δ levels in diabetic neuropathy (DN) and its adverse effects on handwriting. One hundred diabetic neuropathy patients (DNP) were compared with 100 diabetic patients(DP) and 100 healthy volunteers. ALR -106C→T and -12C→G variants were studied using the PCR-RFLP method. Individuals carrying ALR-106C→C and -12G→G had a significantly higher risk of developing DN than individuals with -106C→T and -12C→G genotypes. Carriers of the (-106C→T) CC and (-12C→G) GG genotypes had significantly increased serum levels of PKC-δ, fasting blood glucose (FBG), total cholesterol (TC), and low-density lipoprotein-cholesterol (LDL-c) serum levels. All DNP showed complete deterioration of handwriting.