الفهرس | Only 14 pages are availabe for public view |
Abstract Abstract Background: Sepsis represents a major cause of morbidity and mortality in pediatric burn patients as this patient sub-population comprises many factors affecting cellular and humoral immunity, viz., depressed serum immunoglobulin G (IgG) levels due to loss and immature synthesis, in this age group. Also, IgG levels’ deficiency aggravates the risk for TSS development. Besides, the loss of skin integrity facilitates colonization and subsequent infection and sepsis. Besides aggressive antimicrobial administration, intravenous immunoglobulin is presumed to decrease sepsis and TSS development through providing passive immunization for the patients at the time of immunosuppression and neutralizing TSS-1 toxin if the patient developed TSS. |