الفهرس 
Association of serum osmolarity with contrast-induced nephropathy in patients undergoing percutaneous coronary intervention
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Abstract
It has been shown that revascularization may bring benefit to cardiac patients by restoring the normal function after improving ischemia. Patients with serious cardiac insufficiency caused by ACS complicated with severe heart failure, chronic ischemic heart disease and coronary heart disease associated with other types of heart disease (valvular heart disease) can benefit from elective PCI.
Contrast-induced nephropathy (CIN) is a prevalent and serious complication of numerous radiological procedures that expose patients to contrast media. The most notorious of these procedures is percutaneous coronary intervention (PCI). We evaluated the predictive value of serum osmolarity for CIN development in patients who underwent PCI(elective or primary). The study population was divided into 2 groups according to CIN development, and both groups were compared according to clinical, laboratory, and demographic features, including the serum osmolarity. Serum osmolarity was significantly higher in patients with CIN than in those without CIN .There were 31 (15.5%) patients who had CIN.Multivariate analysis showed that pre-procedural serum osmolarity and contrast volume are independent predictors of CIN.By ROC analysis, the best cutoff for serum osmolarity level to predict the occurrence of CIN was 298.25, with 100% sensitivity and 98.2% specificity (area under the curve = 0.984, 95% CI: 0.966-1.002; p < 0.001).So, Serum osmolarity calculation can be used among predictors of CIN.