الفهرس 
EPIDEMIOLOGY AND RISK FACTORSOnly 14 pages are availabe for public view
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Abstract
lorectal cancer (CRC) is already the third leading cause
of cancer death in the world, and its incidence is steadily
rising in developing nations (Ferlay et al., 2018).
According to GLOBOCAN 2020, more than 1.9 million
new cases of colorectal cancer (1,148,515 of the new cases are
colon cancer with 6% percent of total new cases) and more than
930 000 deaths due to colorectal cancer (576,858 due to colon
cancer) were estimated worldwide. Large geographical
variations in incidence and mortality rates were observed. The
incidence rates were highest in Europe and Australia and New
Zealand, and the mortality rates were highest in Eastern Europe
(Ferlay et al., 2022).
Colorectal cancer is the third in incidence, but second in
mortality. Incidence rates are approximately 4-fold higher in
developed countries compared with developing countries, but
there is less variation in the mortality rates because of higher
fatality in developing countries. There is an approximately 9-
fold variation in colon cancer incidence rates by world regions,
with the highest rates in European regions, Australia/ New
Zealand, and Northern America, with Hungary and Norway
ranking first in men and women, respectively. Colon cancer
incidence tends to be low in most regions of Africa and in
South Central Asia (Siegel et al., 2021).
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