الفهرس | Only 14 pages are availabe for public view |
Abstract Background: The standard of care (SOC) for treatment of patients with locally advanced cervical cancer includes Concurrent Chemoradiotherapy (CCRTH) followed by intracavitary brachytherapy. This modality represents a challenge for the oncologists especially in countries with lack of brachytherapy centers. An alternative method of treatment can be applied; radical hysterectomy following neoadjuvant therapy, yet with limited efficacy data. Aim of work: We aimed to investigate the loco-regional control rate and survival data in those patients and compare it with those who received the SOC. Patients and methods: A retrospective analysis involving patients with pathologically proven cervical cancer, with FIGO stages IB2 till IVA who presented to Clinical Oncology Department, Cairo University during the period from January 2015 till December 2020. Data was retrieved from our medical records, including demographic profile, pathological parameters, imaging workup, plan of management and time to occurrence of events. Results: Data analysis showed comparative results between the two arms. Local control was achieved by 83% on regular follow up. The loco-regional control rate in patients who received definitive CCRTH followed by surgery was 75%, while in those who received brachytherapy instead, was 85.3% (P-value= 0.24), there was no significant difference in both groups regarding local control, OS and distant metastasis. Conclusion: In countries where there is lack of brachytherapy centers, Radical Surgery can be offered as a modality of treatment following adjuvant therapy |