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Abstract Background: Inflammation has been shown to play an important role in the mechanisms involved in the pathogenesis of hypertension, Purpose: To evaluate the effect of circuit weight training on tumor necrosis factor-alpha on essential hypertensive patients. Methods: Fifty hypertensive men patients participated in this study, their ages ranged from 40 to 50 years old, with Systolic blood pressure ranged from (140-179) mm Hg and diastolic blood pressure from (90-109) mm Hg. This study was carried out in the period starting from July 2020 till May 2021 participants were selected from Cairo Transport Authority Hospital. They were randomly assigned into two groups: group A (study group) were 30 patients who participated in circuit weight training program performing 3 times per week for 8 weeks in addition to their medical treatment. group B (control group) were 20 patients who received their medical treatment only. Results: Systolic blood pressure decreased by 6.46% in study group while was 1.15% in control group. Diastolic blood pressure decreased by 5.39% in study group while was 0.6% in control group. The tumor necrosis factor alpha decreased by 28.21% in study group while was 1.76% in control group. Heart rate decreased by 5.18% in study group while was 0.43% in control group. Rate pressure product decreased by 10.49% in study group while was 0.76% in control group. . Conclusion : circuit weight training had great effect in decreasing tumor necrosis factor alpha, blood pressure, heart rate and rate pressure produc |