الفهرس 
Prognostic Factors Affecting Survival After Trans-Arterial Radio-Embolization (Tare) In Patients With Unresectable Hepatocellular Carcinoma A Retrospective Study
AbstractOnly 14 pages are availabe for public view
 |  | from | 173 |  |  |
| | | from | 173 | | |
Abstract
Trans-arterial radio-embolization (TARE) is an emerging therapeutic option for advanced-stage hepatocellular carcinoma (HCC). TARE shows promising performance in terms of unresectable HCC tumor response, recurrence and survival. This study aims to determine the prognostic factors that affect the overall survival in patients receiving TARE in treating unresectable HCC.
Methods: The present study was conducted retrospectively on 54 Egyptian patients with HCC attending the multidisciplinary HCC clinic, private sector hospital in the period from January 2015 to January 2017. We included adult patients with preserved liver functions (Modified Child-Pugh class A and B) and Eastern Cooperative Oncology group performance status (ECOG 0,1,2). Patients and tumor characteristics were recorded. HCC treatment response (mRECIST). clinical and biochemical toxicities and overall survival were studied.
Results: The mean age of the studied population was 61.3 years with male predominance (85.2%). The mean tumor size was 9.5x6.8cm. 49 patients (90.7%) were Child-Pugh class A, while 5 patients (9.3%) were class B. Most of the patients were classified as ECOG 0 (51.9%), while 38.9% and 9.3% were classified as ECOG 1 and 2 respectively. By the end of the study, 18 patients (33.3%) died. The median overall survival (OS) was calculated while comparing the alive and dead group of patients. The statistically significant differences between the 2 groups were reported in terms of pre-treatment decompensation (C-PS), performance status (ECOG) and treatment response (mRECIST). Tumor response and pre-procedural performance status were the independent predictor of survival by multivariate logistic regression analysis. Despite the small sample size, TARE showed satisfactory overall survival and optimistic treatment responses.
Conclusion: TARE showed similar satisfactory results in treatment of unresectable HCC, Child-Pugh score, performance status, and mRECIST were found to be important prognostic factors that determine the overall survival post TARE in HCC patients. TARE is a promising alternative for treatment of selected cases with unresectable HCC.