الفهرس 
Evaluation of the anticonvulsant effects of Selenium in an epileptic animal Modle
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Abstract
The present study aims to evaluate the efficacy of selenium (Se) alone
or combined with carbamazepine (CBZ) against the adverse effects induced
by the chemoconvulsant Pentylenetetrazole (PTZ) in the cortex of adult male
rats. Electrocorticogram (ECoG) and oxidative stress markers were
implemented to evaluate the differences between treated and untreated
animals. Animals were divided into five groups; control group that received
i.p saline injection, PTZ-treated group that received a single i.p. injection of
PTZ (60 mg/kg) for induction of seizures followed by a daily i.p. injection of
saline, Se-treated group that received an i.p. injection of sodium selenite
(0.3 mg/kg/day) after PTZ administration, CBZ-treated group that received
orally CBZ (80 mg/kg/day) after PTZ administration, combination (Se plus
CBZ)-treated group that received an oral administration of CBZ (80
mg/kg/day) followed by an i.p. injection of sodium selenite (0.3 mg/kg/day)
after PTZ administration. Quantitative analyses of the ECoG indices and the
neurochemical parameters revealed that Se and CBZ have mitigated the
adverse effects induced by PTZ. The main results were decrease in the
number of epileptic spikes, restoring the normal distribution of slow and fast
ECoG frequencies and attenuation of most of the oxidative stress markers.
However, there was an increase in lipid peroxidation marker in combined
treatment of CBZ and Se. The electrophysiological and neurochemical data
proved the potential of these techniques in evaluating the treatment’s
efficiency and suggest that supplementation of Se with antiepileptic drugs
(AEDs) may be beneficial in ameliorating most of the alterations induced in
the brain as a result of seizure insults and could be recommended as an adjunct
therapy with AEDs.