الفهرس 
Design and synthesis of some novel quinolone derivatives with potential antimicrobial activity
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Abstract
Fluoroquinolones are a class of antibacterial agents used clinically to treat a wide
array of bacterial infections. Although being potent, susceptibility to CNS side
effects limits their use. It was observed that improvements in absorption, activity and
side effects were achieved via modifications at the C7 side chain. To meet the
increasing demand for development of new antibacterial agents, nineteen novel
ciprofloxacin-sulfonamide hybrid molecules were designed, synthesized and
characterized by IR, 1H NMR and 13C NMR as potential antibacterial agents with
dual DNA gyrase/topoisomerase IV inhibitory activity. Most of the synthesized
compounds showed significant antibacterial activity that was revealed by testing
their inhibitory activity against DNA gyrase, DNA topoisomerase IV as well as their
minimum inhibitory concentration against Staphylococcus aureus.