الفهرس 
Introduction and Review of LiteratureOnly 14 pages are availabe for public view
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Abstract
Periodontal disease is a common oral disease. Periodontal disease is an inflammatory disease mediated by bacterial dysbiosis. Periodontal disease identified by severe inflammation and loss of periodontal- supporting tooth apparatus. The objective of periodontal treatment are arrest any progression of disease and regenerate what have been lost by periodontal destruction.
The objective of the present study is to evaluate the effect of ozonized olive oil by bone morphogenic protein level in cervicular gingival fluid and to evaluate the clinical and intrabony defect fill outcome after surgical treatment of intra-bony defects.
Ozonized olive oil has many biological effect on different tissues, antimicrobial, immune-stimulating, anti-hypoxic, biosynthetic.
The present study entailed thirty patients having stage II or stage III, Grade (A) periodontitis with 30 intra-bony defects. Patients were divided into three groups; group I was subjected to open flap debridement with placing xenograft bone graft only. group II was subjected to open flap debridement with placing xenograft bone graft with ozonated olive oil. While group III was subjected to open flap debridement with placing xenograft bone graft with ozonated oil with further application of ozonated oil every week for subsequent 3 weeks topically.
Clinical parameters including plaque index, gingival index, probing depth and clinical attachment level were recorded pre-surgical. Moreover, Radiographic examination was performed by digital periapical films using parallel technique before the surgery. Vertical bone defects were exposed by full thickness mucoperiosteal flap following intrasulcular incision and thorough debridement was performed. group I received bone substitute (xenograft) only. group II received bone substitute (xenograft) with ozonized olive oil. group III received bone substitute (xenograft) with ozonized oil with further application of ozonized oil once a week in following 3 weeks.
The same initial clinical parameters were recorded three and six months postoperatively. Radiographic measurements were recorded six months post surgically.
In this study result reveled, all clinical parameters including plaque index, gingival index, probing depth, and clinical attachment level show no significant difference between groups. However, each group shows a statistically significant in during each interval.
Regarding the radiographical results, all groups showed no significant difference at 6 months.
Regarding gingival cerviular fluid Bone Morphogenic protein 2 level, each group a showed a significant difference for different intervals at 1, 3, 7, 14, and 21 days. For group I, gingival cervicular fluid of BMP2 at 21days declined. All groups showed no statistically difference through different interval of times during till week two, but before surgery till week three shows a significant difference between groups, with a significant difference between group I and group II. And no significant difference between group II and group III.