الفهرس 
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Abstract
Neonatal sepsis is one of the most prevalent infections. Our objective is to determine the bacteria that cause sepsis in newborns of Egyptian hospitals and their resistance profiles to select the appropriate drug combinations against multidrug resistant bacteria. 989 blood samples collected from neonates within two years. Bacterial identification and antimicrobial susceptibility test performed using VITEK® 2 system. Quantitative RT-PCR analysis of the blaCTX-M-15 gene expression of MDR K. pneumoniae isolates expressed the gene at a significantly higher level than susceptible isolates. In conclusion, Klebsiella pneumoniae is the leading cause of neonatal sepsis in the majority of Egyptian hospitals’ NICUs.