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العنوان
Enantioseparation and quantitative determination of some chiral switching drugs /
الناشر
Lobna Mohammed Abdelhalim ,
المؤلف
Lobna Mohammed Abdelhalim
هيئة الاعداد
باحث / Lobna Mohammed Abdelhalim
مشرف / Laila Elsayed Abdelfattah
مشرف / Maissa Yacoub Salem
مشرف / Nahla Nour Eldin Ahmed Salama
تاريخ النشر
2015
عدد الصفحات
264 P. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الصيدلة ، علم السموم والصيدلانيات (المتنوعة)
تاريخ الإجازة
11/5/2015
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - Analytical Chemistry
الفهرس
Only 14 pages are availabe for public view

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Abstract

The aim of this work is development and validation of new analytical techniques for enantioseparation and quantitative determination of some chiral switching drugs. In this thesis, zopiclone, ofloxacin, atracurium mesylate, ibuprofen, atropine sulphate, ketoprofen, and citalopram, were chosen to be studied as representative examples of chiral switching drugs to pure isomers, eszopiclone, levofloxacin, cisatracurium mesylate, dexibuprofen, hyoscyamine sulphate, dexketoprofen, escitalopram oxalate. The accuracy, selectivivity and applicability of the developed methods to the determination of enantiomeric purity and assay of chiral drugs in drug substances and drug products in QC laboratories were also studied