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Abstract
Background: The clinical outcome of hepatitis C virus infection varies between individuals {u2013} from spontaneous viral clearance and persistence without complication, to chronic hepatitis, cirrhosis and hepatcellular carcinoma. This diversity includes the alterations in genes encoding cytokines responses. Objective: In this study, we investigated Interleukin-10 loci (at positions {u2212}1082(G/A), {u2212}819(C/T) and {u2212}592(C/A)),in determing the outcome of HCV infection, its critical role as a marker for treatment response and development of fibrosis in the Egyptian patients infected with HCV genotype 4. Patients and methods: This study was conducted on 97 Egyptian patients with HCV infection who received Pegelated IFN + Ribavirin treatment for 48 weeks. The study was also conducted on 50 healthy controls (with negative results for HCV antibody and RNA PCR). Full history of patients in this study was recorded