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Abstract
The aim of this study was to detect level of salivary CD44 in oral smoker{u2019}s keratosis (SK) and candidal leukoplakia (CL) and correlate it with epithelial dysplasia and the possibility of malignant transformation. This study was performed on a total of 35 patients divided into 3 groups; 15 patients having SK lesions, 5 patients having candidal CLlesions and 15 healthy control individuals. The levels of CD44 were measured in the saliva of all patients and controls by ELISA Kits and correlated with the presence or absence of epithelial dysplasia in both lesions. There was a statistically significant difference (p < 0.001) between mean value of salivary sCD44 (22.17 ng / ml ( ± 7.52)) in the SK group and that of the control group (10.034 ng / ml ( ± 2.30)). The CL group showed a statistically significant difference (p < 0.001) between the mean level of salivary sCD44 and that of the control. There was no statistically significant difference (p < 0. 388) between the mean level of salivary sCD44 amongst SK and CL group. It was found that there was an increase in the dysplastic changes among groups with more mean value of sCD44