الفهرس 
Impact of extracoronary calcification and pericardial fat volume on extent of coronary artery disease in patients with type 2 diabetes mellitus
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Abstract
Background:Type 2 diabetes mellitus (T2DM) isnowconsidered a coronary artery disease (CAD) equivalent. We hypothesized that coronary artery calcium score (CACS), extracoronary calcium score (ECCS) and pericardial fat volume (PFV) may represent useful additional markers for risk assessment in diabetic patients. Methods:This prospective study was conducted on 1032 patients. They included 402 patients with T2DM. Using multidetector computed tomography (MDCT), we assessed PFV, CACS and ECCS.The severity of CAD was quantified using the Gensini Score. Correlation between CACS, ECCS and PFV and severity of CAD was studied. Results: Diabetic patients with ECCS > 0 in comparison with diabetic patients with ECCS=0 had higher CACS (163 ± 239 vs. 72 ± 176, p< 0.000), higher Gensini score (22.3 ± 31.6 vs. 9.7 ± 16.3, p< 0.000) and higherprevalence of patients with Gensini score > 0 (p< 0.000). There was a significant linear correlation between ECCS and Gensini score (r=0.328, p<0.001). Comparing diabetic patients with PFV {u2265} 100 cm3 with diabetic patients with PFV < 100 revealed that prevalence of patients with Gensini score>0 was not significantly higher in patients with PFV{u2265}100 cm3 (p = 0.205). Gensini score also was not significantly different between the 2 groups (13.9 ± 25.1 vs. 12.8 ± 21.3, p = 0.370). Logistic regression analysis was applied to detect possible association between age, male gender, hypertension, diabetes mellitus duration, CACS, ECCS, PFV and Gensini score >0. Male gender (OR = 3.021, p = 0.007, 95% CI: 1.352-6.750), and CACS (OR=1.021, P< 0.000, 95% CI: 1.011-1.031) were the only independent predictors of Gensini score > 0. Conclusion: In T2DM, neither ECCS > 0 nor PFV{u2265}100 cm3were predictors of Gensini score>0. Male gender and CACS were independent predictors of Gensini>0