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Abstract
Different methods for the determination of some antibacterial drugs, in bulk, dosage forms and in human plasma have been introduced in this thesis. These drugs are ciprofloxacin hydrochloride, norfloxacin, metronidazole and tinidazole. chromatographic part includes HPLC determination of some mixtures namely a binary mixture of ciprofloxacin and metronidazole in absence or in presence of acid degradation product of ciprofloxacin and a tertiary mixture of norfloxacin, metronidazole and tinidazole. An UHPLC determination of the tertiary mixture and a stability indication determination of norfloxacin in presence of its acid induced degradation product was applied together with a simultaneous determination of ciprofloxacin in presence of its acid induced degradation product with monolithic column. In addition to a determination of ciprofloxacin in presence of one of its metabolites after being synthesized, in spiked human plasma using UHPLC was proposed. Also, the chromatographic part includes UHPLC-MS/MS simultaneous determination of ciprofloxacin and metronidazole in spiked human plasma