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Abstract
The current study is designed to compare the efficacy of post partum rectal misoprostol in addition to intra operative IV oxytocin to intra-operative IV oxytocin alone during cesarean delivery to reduce intra - operative and post operative blood loss. This is an interventional prospective controlled study assessing the use of postpartum rectal misoprostol in addition to intraoperative IV oxytocin during cesarean delivery to reduce intra operative and postoperative blood loss in comparison with routinely used intra operative intravenous oxytocin injection alone. The Study is composed of 150 women undergoing elective or emergency cesarean delivery under general or spinal anaesthesia, subjects included in the study will be randomized into 2 groups: First group (75 women): will receive post-partum misoprostol 800 ug, administered rectally in addition to intra operative 5 IU of IV oxytocin. Second group (75 women): will receive intra operative 5 IU of oxytocin after the delivery of the neonate as slow IV dose. In our study, differences in the age, parity and gestational age were statistically insignificant among the two groups. In our study, 32 % among the first group patients needed further uterotonic agents compared to 26% of the patients in the other group, also 14.7 % out of the first group needed blood transfusion, compared to 12 % of the second group, which is statistically insignificant