الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Genus Bauhinia (Fabaceae, subfamily caesalpinioideae) is famous for the anti-diabetic and anti- oxidant activities of leaves and stem barks of many of its members. Our study aims to investigate the possible anti-diabetic and/or anti-oxidant activities of Bauhinia vahlii leaves in relation to their major constituents besides the botanical characterization of the plant. The anti-diabetic and anti-oxidant activities were examined by in-vitro assays (Ü-glucosidase inhibition and DPPH scavenging models, respectively) in addition to STZ-induced diabetic rats model. The defatted ethanolic extract of the leaves (DEE) exhibited both enzyme inhibition and DPPH scavenging activities with its ethyl acetate and n-butanol fractions being the most active extractives, respectively. These activities were further confirmed by the in-vivo study. DEE exhibited glucose lowering potential indicated by lowered fasting blood glucose level and reduced glycated hemoglobin (HbA1C) percentage. DEE was also able to ameliorate oxidative stress resulted from the induced diabetes. This was revealed by increased total anti-oxidant capacity and elevated hepatic level of reduced glutathione (GSH) in the DEE treated groups besides the reduced hepatic levels of both nitric oxide and malodialdehyde. Furthermore, DEE protected the liver from signs of toxicity, caused by diabetes and increased oxidative stress, detected in diabetic untreated rats. This protective action was concluded by normalized levels of liver enzymes and normal histopathological features of liver tissues (c.f. those of diabetic untreated rats).