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Abstract
Postoperative CSF and surgical site infection in patients undergoing cranial neurosurgical procedures is a challenging issue that may result in serious morbidity & mortality Results The overall incidence of meningitis was 3.5% in the pre-protocol group & 2.1% in the post-protocol group.The incidence of SSI was 4 % in the pre- protocol group & 3.5 % in the post-protocol group. The most common organisms causing meningitis & SSI were Klebsiella, Enterococci, Staph-aureus, Acinatobacter, E-coli & Pseudomonas MRSA.The following organisms [Pseudomonas, Enterococci, Ecoli & MRSA] decreased in the period following application of the protocol, while [Stahp-aureus & klebsiella] increased in the period following application of the protocol, although neither the decrease nor the increase were statistically significant. Conclusion Although the incidence of infection decreased after application of protocol this was not statistically significant, this may require a longer period of observation and modification of the prophylactic antibiotic protocol considering the variation of the organisms & results of positive cultures.