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العنوان
Synthesis and reactions of some new azoles and their corresponding fused derivatives of expected biological activity /
الناشر
Ebrahim Adelebrahim Eldesoky ,
المؤلف
Ebrahim Adelebrahim Eldesoky
هيئة الاعداد
باحث / Ebrahim Adelebrahim Eldesoky
مشرف / Nadia Hanafy Metwally
مشرف / NadiHanafy Metwally ,
مشرف / Nadia Hanafy Metwally
تاريخ النشر
2016
عدد الصفحات
193 P. ;
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
Organic Chemistry
تاريخ الإجازة
11/5/2016
مكان الإجازة
جامعة القاهرة - كلية العلوم - Organic Chemistry
الفهرس
Only 14 pages are availabe for public view

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from 280

Abstract

5-Hydrazinylmethylene-2-thioxo-4-thiazolidinone derivative was prepared and taken as a synthetic precursor for the synthesis of different pyrazoles and indazoles-based derivatives. 5-Cycloalkylidene-2-thioxo-4-thiazolidinone derivatives were prepared and their synthetic potential was investigated to prepare various N-substituted and S-substituted 4-thiazolidinone derivatives. 2-Thioxo-4- thiazolidinone was used to construct new 1,4-bis[thiazolidin-5- ylidenemethyl]benzene derivative as a precursor for novel bis-polysubstituted thiazolidinones of interesting biological activity. 4-Thioxo-2-thiazolidinone reacted with 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehydes to give the corresponding 5- arylmethylene derivatives which their synthetic potential, as reactive dienes, was investigated against different dienophiles in, regioselective and stereoselective, hetero-Diels-Alder reactions to give the corresponding pyrazole-based thiopyrano[2,3-d]thiazole derivatives. Structures of all newly synthesized heterocyclic compounds were established by considering the data of both spectral data (X-ray, NMR, Mass and IR) and elemental analysis.