الفهرس | Only 14 pages are availabe for public view |
Abstract This thesis involved analytical study of some drugs containing hydroxyl group and described simultaneous analysis of binary and ternary mixtures by applying chromatographic, spectrophotometric (univariate and multivariate), and electrochemical methods. The aim of work was to develop several simple, accurate, sensitive, selective and precise methods for the assay of the studied drugs (prednisolone acetate, sulfacetamide sodium, hydrocortisone acetate, and clioquinol) in their pure powdered form, laboratoryprepared mixtures and pharmaceutical formulation. The developed methods were applied on topical preparations including Blephamide® eye drops and Vioderm Hydrocortisone® Cream. All the proposed methods were validated according to ICH guidelines and the obtained results were statistically compared with those of the official and/or reported methods using Student’s t-test, F-value and one-way ANOVA that showing no significant difference with respect to accuracy and precision. These methods could be used for the routine analysis of the studied drugs in quality control laboratories with satisfactory accuracy and precision. |