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Abstract Summary The spleen forms part of the reticuloendothelial system of the human body. It is in the Posterolateral aspect of the left hypochondrial area of the abdominal cavity closely related to the stomach, tail of pancreas, splenic flexure of the colon and the diaphragm. Diseases of the spleen and trauma may lead to the need for the removal of the spleen which warrants a surgical procedure. Common indications for splenectomy include Hematologic diseases, staging for Hodgkin‘s lymphoma and other pathologies. Surgery of the spleen traditionally was done by an open method, which required a big incision in the abdominal wall, followed by long hospital stay and subsequent disfiguring scar. The developments in minimal access surgery, which started in the late 80s and early 1990s, have led to laparoscopic splenectomy as a standard operation for small and medium size spleen and hand-assisted laparoscopic surgery (HALS) for big spleens in selected patients. The benefits of laparoscopic over open surgery included shorter hospital stay, less pain, quick return to work, less tissue trauma and reduced wound complications and better cosmetic results. Most of previous studies depended on length or volume of spleen missing the abdominal topography. Therefore, in our study, we tried to correlate splenic volume and length to abdominal topography for the best laparoscopic splenectomy approach in relation to the upper abdominal room and volume. This prospective study was carried out on 30 patients allocated into two groups; 20 patients were subjected to laparoscopic splenectomy by |