الفهرس 
Hot-Melt Extrusion Technique for The Formulation of Per-Oral Antiinflammatory Drug Delivery Systems
ContentsOnly 14 pages are availabe for public view
 |  | from | 134 |  |  |
| | | from | 134 | | |
Abstract
Ibuprofen (IBU) is one of the most widely used analgesic–antipyretic anti-inflammatory drug. The main mechanism of action of IBU is the inhibition of prostaglandin synthesis by blocking of cyclo-oxygenase (Cox). IBU inhibit both Cox-1 and Cox-2. IBU has low aqueous solubility (belonging to biopharmaceutical classification system “BCS” Class II) which exhibits a slow oral absorption with delayed onset of action.
Although IBU is almost fully absorbed by the oral route, the rate of absorption is dependent on the dissolution rate of the formula. Thus, poor aqueous solubility of IBU affects its dissolution and bioavailability after oral administration.To overcome this problem, many approaches have been applied to enhance the solubility of IBU such as the use of solid dispersions (SDs) methods, for example the fusion method (traditional technique) or hot melt extrusion (HME) as a novel technique.
HME has been developed as an alternative platform technology to other traditional techniques for manufacturing different pharmaceutical dosage forms. In addition, HME become one of the best pharmaceutical technologies for enhancing dissolution and stabilizing the amorphous state of the drug via the formation of solid dispersions (SDs) with improving both dissolution and oral bioavailability. HME process possess various advantages over conventional approaches as it is a solvent-free, environmentally friendly (green method) process. Furthermore, HME is a continuous process with few steps as well, simple and cost-efficient for scaling-up production.