الفهرس 
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Abstract
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UMMARY
ashimoto’s thyroiditis (HT), the most frequent autoimmune thyroid disorders (AITDs), is the leading cause of hypothyroidism in the iodine-sufficient areas of the world. About 20-30% of patients suffers from HT, whose cause is thought to be a combination of genetic susceptibility and environmental factors that causes the loss of immunological tolerance, with a consequent autoimmune attack to the thyroid tissue and appearance of the disease.
(COVID-19) is a highly transmissible infectious disease caused by the Severe Acute Respiratory Syndrome Virus 2 (SARS-CoV-2), belong to the family of beta-coronaviruses. The disease rapidly spread, leading to COVID-19 pandemic on March 11, 2020.
The thyroid gland and the virus infection with its associated inflammatory-immune responses are known to be engaged in complex interplay.
The aim of this study was to evaluate the thyroid function consequences following either (COVID-19) infection or vaccination, in relation to their clinical features, biochemical, immunological, and inflammatory markers.
This study was a pilot study, conducted on 80 subjects attending COVID vaccination center and Emergency isolation in Ain Shams university hospital during the period from August
H
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to october 2022 14 males, 66 females, age>18 years old and <70 years‘ old to evaluate the thyroid function consequences following either (COVID-19) infection or vaccination, in relation to their clinical features, biochemical, immunological, and inflammatory markers.(initially and after 3 to 6weeks)
group (1): 20Patients with Hashimoto‘s thyroiditis exposed to COVID 19 infection and after 3-to-6-weeks.
group (2): 20Patients with Hashimoto‘s thyroiditis Who got COVID 19 vaccine (AstraZeneca) and after 3-to-6-weeks.
group (3): 20Normal subjects exposed to COVID 19 infection and after 3-to-6-weeks.
group (4):20Normal subjects Who got COVID 19 vaccine and after 3 to 6 weeks. (AstraZeneca).
Our study showed significant increase in the level of TSH and decrease in the level of free T3, Free T4 in Hashimoto‘s patients who exposed to COVID19 infection.
Also it showed significant increase in the level of free T3, Free T4 and decrease level of TSH in normal subjects after exposure to COVID19 infection.
Additionally, our study showed increase level of free T3, Free T4 in normal subjects after being exposed to COVID19 vaccine (AstraZeneca) in contrast to TSH being decreased in them.
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Furthermore , we found significant increase in the level of free T3, Free T4 in Hashimoto‘s subjects after their exposure to AstraZeneca vaccine, with non significant difference regarding –anti- TPO, Antithyroglobulin