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العنوان
A Pharmaceutical Study on Formulation of L-Carnitine in Solid Dosage Forms /
المؤلف
Mahmoud Mohammad Mohammad Hegazy,
هيئة الاعداد
باحث / Mahmoud Mohammad Mohammad Hegazy
مشرف / Alia Abdel-Latif Badawi
مشرف / Mohammed Ahmed Al-Nabarawi
مشرف / Dina Louis Nassif
مشرف / Mohamed Aly Abd El Aziz El-Degwy
الموضوع
Pharmaceutics and Industrial Pharmacy
تاريخ النشر
2022.
عدد الصفحات
166 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الصيدلة
تاريخ الإجازة
11/6/2022
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - Pharmaceutical Industries
الفهرس
Only 14 pages are availabe for public view

from 224

from 224

Abstract

Carnitine is an amino acid derivative which is an essential cofactor of fatty acid metabolism. Carnitine supplementation is used for the management of both primary and secondary carnitine deficiencies. L-carnitine is the biologically active form. L-carnitine is hygroscopic, a fact which presents difficulties in its formulation into tablets including poor flowability, sticking to punches, production of weaker tablets, high ejection forces during tablet compression and poor stability. This work comprises trials to reduce hygroscopicity of the drug to solve its manufacturing associated problems.