الفهرس 
Title : Assessment of contribution of STAT4 gene polymorphisms in diabetes mellitus type 1 incidence among Egyptian patients
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Abstract
Signal transducer and transcriptional activator 4 (STAT4) variants play a
crucial role in developing several autoimmune diseases, including type 1
diabetes (T1D).Diabetes mellitus is a polygenetic disorder includes complex
interaction between genetic and environmental factors, Type 1 diabetes is a
genetic autoimmune disease caused by T-cell-mediated damage of pancreatic
cells that regulate production of insulin with in blood. The current study
sought to shed light on the function of STAT4 (rs7574865) and (rs11889341)
variants allelic and genotypic variations in susceptibility to type 1 diabetes
among Egyptians were discovered using real-time PCR. 100 subjects that have
been diagnosed with T1D were enrolled in this study and 100 healthy subjects
as control group. Clinical data, anthropometric measurements and the
polymorphisms (rs11889341 & rs7574865) of STAT4 gene were genotyped
among all subjects. This study confirmed that rs7574865 (T allele and GT
genotype) and the rs11889341 (CT genotype) have a significant association
with diabetes type 1 occurrence among Egyptian patients. Also, these gene
polymorphisms have a significant correlation with other clinical parameters.