الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Background: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is novel discovered, highly contagious and deadly coronavirus in humans that caused worldwide health emergency and socio-economic disasters in general populations. COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19 Multiple studies have shown serum S100B protein concentration is related to diagnosis and prognosis of multiple diseases compared with normal individuals. Few studies referred to association between s100B and SARS CoV-2 patients.Objective: Our Study aimed to assess and associate a novel marker called S100B protein with COVID-19 and its relation to diagnosis and prognosis of the disease. Study locality: Mansoura University Hospitals. Laboratory work was held in Clinical Pathology department, Mansoura University. Study Period: The study had been conducted within one year from 1-2021 to 1-2022. Study design: The study was a case-control study. Study population: 90 patients were selected with Positive PCR for Covid-19 and 30 apparently healthy individuals of matched age and sex as a control group. Methods: Patients and controls in this study were subjected to full history taking, clinical examination and lab investigation including: CBC, liver function test, kidney function test, C-reactive protein, lactate dehydrogenase, D-dimer and S100B. S100B was measured by ELISA method. Results: Covid-19 patients had higher frequency of DM, increased WBCS, INR, CRP, D-dimer, LDH, creatinine, ALT, and AST. Significant reduction of Hemoglobin, lymphocyte and albumin. We found significant elevation of S100B in COVID-19 group compared to control group but no Significant differences with COVID-19 severity or relation to outcome. S100Bshows significant positive correlation with age, LDH and creatinine. Conclusion: 1- Serum S100B concentration is significantly elevated in SARS CoV-2 patients compared to healthy control subjects indicating diagnostic value. 2- No significant difference could be detected in S100B concentration among non-severe, severe and critical groups or with outcome of patients indicating no prognostic or severity classification value.