الفهرس 
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Abstract
AML is a heterogeneous disorder which is represented by the myeloid progenitors characteristic clonal expression involving the bone marrow and peripheral blood. Leukemic myeloid cells gradually replace normal hematopoiesis in bone marrow. The genetically related changes arising in the neoplastic clone can result in cascades of molecular events that lead to abnormal proliferation, aberration, differentiation, and inhibition of normal hematopoiesis by the malignant cells.
LncRNAs are determined as RNA molecules consisting of more than about 200 nucleotides. They are responsible for regulating the expression of gene at the transcriptional, RNA processing, translational, and post‐translational levels by interacting with nucleic acids and proteins. Among the important lncRNA which plays role in different cancer types incidence and progression is HOTAIR.
LncRNAs HOTAIR is expressed by the homeobox C gene occupying the (HOXC) locus and is situated in the HOXC cluster among the HOXC11 and HOXC12 genes on human chromosome 12q13.13 (12).
Ag expression on cell surface are important markers for diagnosis, prognosis and potential treatment implications. The c-kit associated proto-oncogene encodes CD117, a transmembrane receptor protein. In normal hematopoiesis, the C-kit receptor (CD117) and its related ligand, factors linked with stem cell, all display an important role. Meanwhile, when myeloid commitment occurs in leukemias, its expression extremely increases.
The present work aims to assess the correlation between long noncoding RNA HOTAIR and cd117 (c kit) expression among newly diagnosed AML patients.
Our study was done including 25 adults AML suffering patients who are recently diagnosed and 25 patients with non-malignant conditions as controls. All the study involved cases were subjected to full history registering, undergoing clinical examinations & laboratory investigations involving complete blood count & immunophenotyping for diagnosis using acute panel adopted in our department.