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Abstract Background: Knee osteoarthritis (KOA) is the most common chronic degenerative joint disease thataffect the quality of life between older adults, mostly at the age of 45 and older, with percentage of 10% of male and 18% of female population .Weakness of the quadriceps muscle is well reported in subjects with knee OA, It was demonstrated that strengthening the quadriceps muscle result in changes in pain, physical work, and quality of life in knee OA patients.Objective: to investigate the effect of age, body mass index (BMI), duration of symptoms and knee flexion angle on patient response to quadriceps muscle strengthening exercise program in female patients with knee osteoarthritis. Methods: forty female patients were referred by orthopedist to physical therapy department at met fares hospital diagnosed as knee osteoarthritis patient they all met the inclusion criteria then signed a consent Initially, Patients’ personal data, age, body mass index, duration of symptoms and knee flexion angle, in addition to Knee pain intensity level and functional activity level all were recorded in patient evaluation sheet before applying quadriceps muscle strengthening exercise program. Results: The patients’ response to treatment was estimated by calculating the mean difference for pain intensity level (measured via VAS) and the function activity level (measured via 50 feet walk test &time up and go test. The correlation between results before and after Quadriceps muscle strengthening training exercise program showed a significant difference between pre and post 50 feet walk test as regarding (56±12; 39±8respectively), time up and go test(26±8; 18±6 respectively), pain intensity level (VAS) (7±1; 3.5±1.6 respectively), (P value < 0.05). Conclusion: patients’ age, BMI, knee flexion angle& duration of symptoms were difficult to be considered predictors of success to quadriceps muscle strengthening exercise program in female patients with knee osteoarthritis .Knee flexion angle seems to be more common in elder age & overweight female knee osteoarthritis patient. In addition as the duration of symptoms increased the percentage of pain improvement was decreased. |