الفهرس 
Activated partial thromboplastin timeOnly 14 pages are availabe for public view
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Abstract
Thyroid diseases are a common metabolic diseases complex that
affects several people worldwide. Thyroid hormone affect every single
cell in the body through modulations of Oxygen consumption, Growth
rate, Maturation and cell differentiation, Turnover of Vitamins,
Hormones, Proteins, Fat, CHO.
The clinical relationship between thyroid disorders and the hemostatic
system was first defined in the beginning of the last century. Various
acquired abnormalities of the coagulation-fibrinolytic system have been
reported in patients with thyroid dysfunction. These abnormalities may
range from subclinical laboratory abnormalities to clinically important
hemostasis disorders.
The aim of this study is Evaluation of new biomarkers as a predictor for
thrombosis in patients with thyroid dysfunction.
Patients and methods:
This study is a case-control study which enrolled:
1. group A: twenty patients with increased thyroid functions
(hyperthyroidism group).
2. group B: twenty patients with decreased thyroid functions
(hypothyroidism group).
3. group C: twenty subjects with normal thyroid functions (Euthyroid
group).
After taking thorough medical history (Including age, Sex, Smoking,
History of malignancy, Thromboembolic events or bleeding disorders,
Drug intake including OCPS). And full clinical examination was done.
Blood samples were collected for routine labs and measurement of CBC,
PT, PTT, PC, TSH, FT4, D. DIMER and P. selectIN LEVEL. Data
analysis performed using the Statistical Package of Social Science (SPSS)
software version 22 in windows 7 (SPSS Inc., Chicago, IL, USA).
Results: There was no significant difference between study groups As
regards CBC components, PT-INR, PTT and D-dimer level.
The p-selectin level was higher in hyperthyroidism group than
hypothyroidism group. Also, there was significance predictor to PTT and
PLT count level in relation to p-selectin level.
Conclusion, it can be concluded that there was no significant
difference between study groups As regards CBC components, PT-INR,
PTT and D-dimer level. Also p-selectin level was higher in
hyperthyroidism group than hypothyroidism group.
Key words: Thyroid diseases, thrombosis, hemostasis.