الفهرس 
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Abstract
SUMMARY
There is a complicated etiology to vitiligo, a common skin depigmenting illness that is influenced by numerous inherited genes and environmental stimuli. Until recently, the chemical mechanism behind what causes vitiligo was unknown.
There are now various hypotheses presented to explain the processes of pigmentation loss. These hypotheses range from the involvement of the immune system to the role of neurotoxic substances to the inheritance of a predisposition for pigment loss. More recently, researchers have investigated the potential function of genetic polymorphisms and noncoding RNAs in the development of vitiligo. Polymorphisms in genes may take many forms, such as SNPs (single nucleotide polymorphisms), insertions, deletions, inversions, and translocations of chromosomes.
MicroRNA-337 is implicated in a wide variety of pathologies. During liver cell development, for instance, microRNA-337 may control gene expression and transcription. By suppressing the expression of MZF1 (myeloid zinc finger 1), microRNA-337 aids in the development of stomach cancer. Matrix metalloproteinase-14 (MMP-14) expression is suppressed by microRNA-337, which in turn slows the development of neuroblastoma.
Furthermore, the function of microRNA-337 in osteoarthritis, melanoma, and pancreatic cancer has been documented. However, microRNA-337’s significance in Vitiligo has not been investigated. Studying the role of microRNA-337 in Vitiligo is crucial for understanding the condition and developing effective treatments.
We conducted a case-control research on 52 people at the dermatology clinic of Beni-Suef university hospital, randomly assigning 26 of them to the vitiligo group and the other 26 to the control group. Individuals with vitiligo provided their medical history, physical, and blood samples. The levels of miRNA337 in the blood were compared between the two groups using real time PCR.
MiRNA 337 levels in the blood were decreased by a factor of two in patients compared to controls. Females had slightly greater miRNA 337 levels in their blood than men did, but this difference was not statistically significant. There was no association between VASI score, family history, or precipitating circumstances and miRNA 337 levels in the blood.
The results of this research showed an inverse association between miRNA 337 levels and vitiligo severity as measured by the VASI.