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العنوان
Assessment of DNA content by flow cytometry and immunohistochemical expression of BUBR1 in oral epithelial dysplastic Lesions /
الناشر
Sara Mohammed Abdelwahed ,
المؤلف
Sara Mohammed Abdelwahed
هيئة الاعداد
باحث / Sara Mohammed Abdelwahed
مشرف / Naglaa Mohamed Elhossary
مشرف / Safa Fathy Abdelghani
مشرف / Abeer Mostafa Elsayed
تاريخ النشر
2014
عدد الصفحات
115 Leaves :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
Dentistry (miscellaneous)
تاريخ الإجازة
23/3/2015
مكان الإجازة
جامعة القاهرة - الفم والأسنان - Oral Pathology
الفهرس
Only 14 pages are availabe for public view

from 131

from 131

Abstract

Oral epithelial dysplasia represents a relatively late phase in the multistage process of oral carcinogenesis, which is one of the most frequent cancers in the world. Accordingly, our goal was to assess the DNA ploidy status and the immunohistochemical expression of BUBR1 in oral epithelial dysplasia and oral squamous cell carcinoma, correlation of our results with the histopathological findings and evaluation of their diagnostic and prognostic significance. Forty paraffin blocks were investigated and divided into: low and high risk dysplasia, well, moderately and poorly differentiated squamous cell carcinoma. Flow cytometry was used to evaluate the ploidy status, DNA index and S-phase fraction. Immunohistochemical expression of BUBR1 and the area percentage of the positive cells were detected