الفهرس 
Study of the anti-inflammatory and analgesic effects of a certain natural product and selenium nanoparticles in experimentally induced models in gamma irradiated rats
ContentsOnly 14 pages are availabe for public view
 |  | from | 172 |  |  |
| | | from | 172 | | |
Abstract
Aim: To investigate the anti-inflammatory and analgesic effects of piperine and selenium nanoparticles (Nano-Se) using carrageenan-induced paw edema and hyperalgesia model and six-day old air pouch model in non-irradiated and irradiated rats. Materials and methods: Animals were exposed to a single radiation dose level of 6 Gy. Each of piperine 50 mg/kg, Nano Se 2.55 mg/kg and their combination was administered orally. In carrageenan-induced paw edema and hyperalgesia model, the paw volume and nociceptive threshold were measured 3 hours after carrageenan injection. In the six-days old air pouch model, the exudate was collected 6 hours after carrageenan injection for estimation of biochemical parameters. Results: The inflammatory but not the nociceptive response produced by carrageenan in irradiated rats was significantly higher than that induced in non-irradiated rats. Each of piperine, Nano-Se and their combination was effective in reducing the paw volume in non-irradiated and irradiated rats