الفهرس 
MicroRNAs as promising novel biomarkers for diagnosis of breast cancer
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Abstract
Breast cancer is currently the most common cancer in women worldwide, both in developed and developing countries. MicroRNAs (miRNAs) are approximately 22 nucleotides long, single - stranded, non - protein - coding RNA molecules that regulate gene expression. The level of miRNAs altered during inflammatory reaction and tumorigenesis. MiRNAs are stable in the circulation and resistant to RNase digestion and other harsh conditions such as extreme PH, boiling, and multiple freeze - thaw cycles. Its level in circulation is changed in association with different diseases as well as certain biological or pathological stages. MicroRNA - 21, 155 is up regulated and micro RNA 145 is down regulated in many tumors. This study aimed to evaluate the ability to use the microRNA - 21, 155 and micro RNA 145serum level as novel new biomarker to diagnose breast cancer