الفهرس 
The effect of single nucleotide polymorphism in cyclooxygenase - 2 on the treatment of chronic and aggressive periodontitis
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Abstract
Detect single nucleotide polymorphisms in cyclooxygenase - 2 gene at - 1195G / A and - 765G / C , determine the frequency of polymorphisms in Egyptian population with chronic periodontitis and aggressive periodontitis and evaluate the effect of single nucleotide polymorphisms of the cyclooxygenase - 2 gene on the clinical picture and treatment outcome of chronic periodontitis and aggressive periodontitis. The study included a total of 50 individuals that were divided into 3 groups; HC group with clinically healthy periodontium, diseased control group suffering from CP and patients’ group suffering from AP. Patients and healthy controls received a full-mouth periodontal examination which included gingival index, periodontal probing depth, and clinical attachment level. The clinical diagnosis was confirmed by taking full - mouth periapical radiographs. Patients were divided into two groups; group I A.P patients and group II C.P patients, both were treated nonsurgical with follow up (baseline, 1month, 2months and 3 months). Venous blood was taken by standard venipuncture and placed into sterile EDTA - containing tube for DNA extraction and amplification by RFLP - PCR technique. The resulting fragments were separated by agarose gel electrophoresis and visualized by ethidium bromide staining and UV light