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Abstract
Thesis is focused on the determination of lidocaine hydrochloride (LDHC) as a local anesthetic drug. A potentiometric method based on modified screen-printed and modified carbon paste ion-selective electrodes was described for the determination of LDHC in different pharmaceutical and water samples. It is based on potentiometric titration of LDHC using modified screen-printed (MSPE) and carbon paste (MCPE) as end point indicator sensors. The influences of the paste composition, different conditioning parameters and foreign ions on the electrodes performance were investigated and response time of the electrodes has been studied. The electrodes showed Nernstian response of 58.9 and 57.5 mV decade-1 in the concentration range of 1{u00D7}10-7{u2013}1{u00D7}10-2 and 6.2{u00D7}10-7{u2013}1{u00D7}10-2 mol L-1 for MSPE and MCPE, respectively