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Abstract
Background: Transcatheter aortic valve implantation (TAVI) is a treatment option for elderly with severe aortic stenosis (AS). Severe AS in elderly is associated with increased aortic stiffness. Carotid femoral pulse wave velocity (CF-PWV) is robust surrogate of aortic stiffness. The effects of TAVI on aortic stiffness as measured by CF-PWV in elderly with severe AS are not known. Objective: Study the effect of TAVI in patients with severe AS on aortic stiffness and left ventricular (LV) function and the correlation between aortic stiffness and LV function indices before and after TAVI. Patients and Methods: We measured CF-PWV in 36 consecutive patients before and 4-months after TAVI. Results: Aortic valve area increased (1.71 ± 0.34 cm2 vs. 0.74 ± 0.20 cm2, p < 0.001) and mean blood pressure gradient across the aortic valve (10 ± 4 torr vs. 48 ± 19 torr, p < 0.001) decreased after TAVI. CF-PWV (11.3 (9.5, 14.6) m/s) did not significantly change after TAVI compared to baseline (10.5 (9.6, 14.5) m/s, p = 0.17. CF-PWV at baseline correlated with heart rate (r= 0.56, p< 0.001), Aortic regurgitation grade (r= -0.38, p= 0.022), stroke volume index (r= -0.40, p= 0.031) and grade of LV diastolic dysfunction (r= 0.49, p= 0.008)