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Abstract
Ceruloplasmin, haptoglobin and hemopexin are predominantly liver-synthesized acute phase proteins that can have important anti-inflammatory activity through inhibition of oxidative stress, and iron sequestration resulting in antimicrobial activity. They may function to modulate the systemic inflammatory response to inflammation in bronchial asthma and may be involved in tissue repair through fibrosis and angiogenesis in bronchial asthma. This is a cross sectional study aimed to study the serum level of ceruloplasmin, haptoglobin and hemopexin in stable asthmatic children and during acute exacerbations and the relation between serum levels of these proteins and spirometric parameters. Sixty children with moderate to severe persistent asthma aged from 6-13 years were recruited from Pulmonology and Allergy clinic of Specialized Children’s Hospital, Cairo University, and studied in comparison to thirty nonatopic, non-asthmatic children