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Abstract
C-reactive protein (CRP) is a biological marker of systemic inflammation, produced by liver, (Ridker et al., 2001) and increase after estrogen adminstration (Kluft et al., 2002). CRP can be increased after hormonal stimulation; the changes of CRP may affect sucess of in-vitrofertilization. Controlled induction of ovulation of the ovaries, and especially puncture of the ovaries in IVF or intra cytoplasmic sperm injection (ICSI) Cycles is probably associated with some degrees of tissue damage and therefore changes in CRP concentration (wunder BM et al., 2005) these changes may affect the sucess rate of IVF/ ICSI, implantation, and pregnancy (orvie to R et al., 2004).