الفهرس Only 14 pages are availabe for public view
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Abstract
Hepatic fibrosis is an indicator for treatment and a major independent predictor of treatment response in patients with chronic hepatitis C. Liver biopsy which is considered to be the 2gold standard3 for evaluating liver fibrosis is not without drawbacks. Currently used noninvasive predictors of fibrosis are considered less accurate than liver biopsy. To evaluate effectiveness of RDW to platelet ratio as a simple non-invasive model for prediction of degree hepatic fibrosis in patients with chronic hepatitis C virus (HCV) infection and comparing its diagnostic validity to liver biopsy. A cross sectional study including 197 Egyptian patients with chronic hepatitis C. Routine pre-treatment workup with reference needle liver biopsy were performed. Fib - 4, TE by Fibroscan, AST to platelet ratio index (APRI) and RPR (RDW to platelet ratio) were validated. Patients were divided once into two groups, first with insignificant fibrosis (< F2), and second with significant fibrosis ({u2265} F2) and once divided into group of advanced fibrosis ({u2265}F3) and non-advanced fibrosis using the metavir score